A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review)

Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions,...

Descripción completa

Detalles Bibliográficos
Autores principales: FAN, YUN-LONG, ZHENG, MIN, TANG, YA-LING, LIANG, XIN-HUA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813799/
https://www.ncbi.nlm.nih.gov/pubmed/24179490
http://dx.doi.org/10.3892/ol.2013.1555
Descripción
Sumario:Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidence suggests that CSCs are involved in VM formation. Recent studies have indicated that EMT is relevant to the acquisition and maintenance of stem cell-like characteristics. Thus, in this review we discuss the correlation between CSCs, EMT and VM formation.

Ejemplares similares