Cargando…
Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review
Ochratoxin A (OTA) is a mycotoxin involved in the development of different types of cancers in rats, mice and humans. A growing number of in vitro and in vivo studies has been collected and has described evidence compatible with a role for oxidative stress in OTA toxicity and carcinogenicity. Becaus...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813909/ https://www.ncbi.nlm.nih.gov/pubmed/24152986 http://dx.doi.org/10.3390/toxins5101742 |
_version_ | 1782289177627328512 |
---|---|
author | Sorrenti, Valeria Di Giacomo, Claudia Acquaviva, Rosaria Barbagallo, Ignazio Bognanno, Matteo Galvano, Fabio |
author_facet | Sorrenti, Valeria Di Giacomo, Claudia Acquaviva, Rosaria Barbagallo, Ignazio Bognanno, Matteo Galvano, Fabio |
author_sort | Sorrenti, Valeria |
collection | PubMed |
description | Ochratoxin A (OTA) is a mycotoxin involved in the development of different types of cancers in rats, mice and humans. A growing number of in vitro and in vivo studies has been collected and has described evidence compatible with a role for oxidative stress in OTA toxicity and carcinogenicity. Because the contribution of the oxidative stress response in the development of cancers is well established, a role in OTA carcinogenicity is plausible. Several studies have been performed to try to counteract the adverse effects of oxygen radicals generated under OTA-exposure. A number of molecules with various antioxidant properties were tested, using in vivo or in vitro models. Protection against OTA-induced DNA damage, lipid peroxidation, as well as cytotoxicity were observed, further confirming the link between OTA toxicity and oxidative damage. These studies demonstrated that antioxidants are able to counteract the deleterious effects of chronic consumption or exposure to OTA and confirmed the potential effectiveness of dietary strategies to counteract OTA toxicity. |
format | Online Article Text |
id | pubmed-3813909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38139092013-10-31 Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review Sorrenti, Valeria Di Giacomo, Claudia Acquaviva, Rosaria Barbagallo, Ignazio Bognanno, Matteo Galvano, Fabio Toxins (Basel) Review Ochratoxin A (OTA) is a mycotoxin involved in the development of different types of cancers in rats, mice and humans. A growing number of in vitro and in vivo studies has been collected and has described evidence compatible with a role for oxidative stress in OTA toxicity and carcinogenicity. Because the contribution of the oxidative stress response in the development of cancers is well established, a role in OTA carcinogenicity is plausible. Several studies have been performed to try to counteract the adverse effects of oxygen radicals generated under OTA-exposure. A number of molecules with various antioxidant properties were tested, using in vivo or in vitro models. Protection against OTA-induced DNA damage, lipid peroxidation, as well as cytotoxicity were observed, further confirming the link between OTA toxicity and oxidative damage. These studies demonstrated that antioxidants are able to counteract the deleterious effects of chronic consumption or exposure to OTA and confirmed the potential effectiveness of dietary strategies to counteract OTA toxicity. MDPI 2013-10-11 /pmc/articles/PMC3813909/ /pubmed/24152986 http://dx.doi.org/10.3390/toxins5101742 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Sorrenti, Valeria Di Giacomo, Claudia Acquaviva, Rosaria Barbagallo, Ignazio Bognanno, Matteo Galvano, Fabio Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title | Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title_full | Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title_fullStr | Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title_full_unstemmed | Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title_short | Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review |
title_sort | toxicity of ochratoxin a and its modulation by antioxidants: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813909/ https://www.ncbi.nlm.nih.gov/pubmed/24152986 http://dx.doi.org/10.3390/toxins5101742 |
work_keys_str_mv | AT sorrentivaleria toxicityofochratoxinaanditsmodulationbyantioxidantsareview AT digiacomoclaudia toxicityofochratoxinaanditsmodulationbyantioxidantsareview AT acquavivarosaria toxicityofochratoxinaanditsmodulationbyantioxidantsareview AT barbagalloignazio toxicityofochratoxinaanditsmodulationbyantioxidantsareview AT bognannomatteo toxicityofochratoxinaanditsmodulationbyantioxidantsareview AT galvanofabio toxicityofochratoxinaanditsmodulationbyantioxidantsareview |