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Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevan...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813912/ https://www.ncbi.nlm.nih.gov/pubmed/24141284 http://dx.doi.org/10.3390/toxins5101799 |
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author | Faioli, Camila Nunes Domingos, Thaisa Francielle Souza de Oliveira, Eduardo Coriolano Sanchez, Eládio Flores Ribeiro, Suzi Muricy, Guilherme Fuly, Andre Lopes |
author_facet | Faioli, Camila Nunes Domingos, Thaisa Francielle Souza de Oliveira, Eduardo Coriolano Sanchez, Eládio Flores Ribeiro, Suzi Muricy, Guilherme Fuly, Andre Lopes |
author_sort | Faioli, Camila Nunes |
collection | PubMed |
description | Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties. |
format | Online Article Text |
id | pubmed-3813912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38139122013-10-31 Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom Faioli, Camila Nunes Domingos, Thaisa Francielle Souza de Oliveira, Eduardo Coriolano Sanchez, Eládio Flores Ribeiro, Suzi Muricy, Guilherme Fuly, Andre Lopes Toxins (Basel) Article Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties. MDPI 2013-10-17 /pmc/articles/PMC3813912/ /pubmed/24141284 http://dx.doi.org/10.3390/toxins5101799 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Faioli, Camila Nunes Domingos, Thaisa Francielle Souza de Oliveira, Eduardo Coriolano Sanchez, Eládio Flores Ribeiro, Suzi Muricy, Guilherme Fuly, Andre Lopes Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title_full | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title_fullStr | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title_full_unstemmed | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title_short | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
title_sort | appraisal of antiophidic potential of marine sponges against bothrops jararaca and lachesis muta venom |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813912/ https://www.ncbi.nlm.nih.gov/pubmed/24141284 http://dx.doi.org/10.3390/toxins5101799 |
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