Cargando…

Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom

Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevan...

Descripción completa

Detalles Bibliográficos
Autores principales: Faioli, Camila Nunes, Domingos, Thaisa Francielle Souza, de Oliveira, Eduardo Coriolano, Sanchez, Eládio Flores, Ribeiro, Suzi, Muricy, Guilherme, Fuly, Andre Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813912/
https://www.ncbi.nlm.nih.gov/pubmed/24141284
http://dx.doi.org/10.3390/toxins5101799
_version_ 1782289178344554496
author Faioli, Camila Nunes
Domingos, Thaisa Francielle Souza
de Oliveira, Eduardo Coriolano
Sanchez, Eládio Flores
Ribeiro, Suzi
Muricy, Guilherme
Fuly, Andre Lopes
author_facet Faioli, Camila Nunes
Domingos, Thaisa Francielle Souza
de Oliveira, Eduardo Coriolano
Sanchez, Eládio Flores
Ribeiro, Suzi
Muricy, Guilherme
Fuly, Andre Lopes
author_sort Faioli, Camila Nunes
collection PubMed
description Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties.
format Online
Article
Text
id pubmed-3813912
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-38139122013-10-31 Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom Faioli, Camila Nunes Domingos, Thaisa Francielle Souza de Oliveira, Eduardo Coriolano Sanchez, Eládio Flores Ribeiro, Suzi Muricy, Guilherme Fuly, Andre Lopes Toxins (Basel) Article Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties. MDPI 2013-10-17 /pmc/articles/PMC3813912/ /pubmed/24141284 http://dx.doi.org/10.3390/toxins5101799 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Faioli, Camila Nunes
Domingos, Thaisa Francielle Souza
de Oliveira, Eduardo Coriolano
Sanchez, Eládio Flores
Ribeiro, Suzi
Muricy, Guilherme
Fuly, Andre Lopes
Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title_full Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title_fullStr Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title_full_unstemmed Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title_short Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
title_sort appraisal of antiophidic potential of marine sponges against bothrops jararaca and lachesis muta venom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813912/
https://www.ncbi.nlm.nih.gov/pubmed/24141284
http://dx.doi.org/10.3390/toxins5101799
work_keys_str_mv AT faiolicamilanunes appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT domingosthaisafranciellesouza appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT deoliveiraeduardocoriolano appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT sanchezeladioflores appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT ribeirosuzi appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT muricyguilherme appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom
AT fulyandrelopes appraisalofantiophidicpotentialofmarinespongesagainstbothropsjararacaandlachesismutavenom