Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility

Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis, which is a phase III objective. Although seamle...

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Detalles Bibliográficos
Autores principales: Kimani, Peter K, Todd, Susan, Stallard, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813981/
https://www.ncbi.nlm.nih.gov/pubmed/23413228
http://dx.doi.org/10.1002/sim.5757

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