Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status

Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI...

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Detalles Bibliográficos
Autor principal: Heinimann, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814007/
https://www.ncbi.nlm.nih.gov/pubmed/24199172
http://dx.doi.org/10.3389/fonc.2013.00272
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author Heinimann, Karl
author_facet Heinimann, Karl
author_sort Heinimann, Karl
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description Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today’s clinical practice.
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spelling pubmed-38140072013-11-06 Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status Heinimann, Karl Front Oncol Oncology Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today’s clinical practice. Frontiers Media S.A. 2013-10-31 /pmc/articles/PMC3814007/ /pubmed/24199172 http://dx.doi.org/10.3389/fonc.2013.00272 Text en Copyright © 2013 Heinimann. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Heinimann, Karl
Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title_full Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title_fullStr Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title_full_unstemmed Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title_short Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability Status
title_sort toward a molecular classification of colorectal cancer: the role of microsatellite instability status
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814007/
https://www.ncbi.nlm.nih.gov/pubmed/24199172
http://dx.doi.org/10.3389/fonc.2013.00272
work_keys_str_mv AT heinimannkarl towardamolecularclassificationofcolorectalcancertheroleofmicrosatelliteinstabilitystatus

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