Adenovirus RIDα uncovers a novel pathway requiring ORP1L for lipid droplet formation independent of NPC1

Niemann–Pick disease type C (NPC) is caused by mutations in NPC1 or NPC2, which coordinate egress of low-density-lipoprotein (LDL)-cholesterol from late endosomes. We previously reported that the adenovirus-encoded protein RIDα rescues the cholesterol storage phenotype in NPC1-mutant fibroblasts. We...

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Detalles Bibliográficos
Autores principales: Cianciola, Nicholas L., Greene, Diane J., Morton, Richard E., Carlin, Cathleen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814149/
https://www.ncbi.nlm.nih.gov/pubmed/24025716
http://dx.doi.org/10.1091/mbc.E12-10-0760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814149/
https://www.ncbi.nlm.nih.gov/pubmed/24025716
http://dx.doi.org/10.1091/mbc.E12-10-0760

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