Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

BACKGROUND: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent o...

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Autores principales: Scelsi, Daniele, Mevio, Niccolò, Bertino, Giulia, Occhini, Antonio, Brazzelli, Valeria, Morbini, Patrizia, Benazzo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814281/
https://www.ncbi.nlm.nih.gov/pubmed/24294181
http://dx.doi.org/10.2478/raon-2013-0059
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author Scelsi, Daniele
Mevio, Niccolò
Bertino, Giulia
Occhini, Antonio
Brazzelli, Valeria
Morbini, Patrizia
Benazzo, Marco
author_facet Scelsi, Daniele
Mevio, Niccolò
Bertino, Giulia
Occhini, Antonio
Brazzelli, Valeria
Morbini, Patrizia
Benazzo, Marco
author_sort Scelsi, Daniele
collection PubMed
description BACKGROUND: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. CASE REPORT: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life. CONCLUSIONS: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.
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spelling pubmed-38142812013-12-01 Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region Scelsi, Daniele Mevio, Niccolò Bertino, Giulia Occhini, Antonio Brazzelli, Valeria Morbini, Patrizia Benazzo, Marco Radiol Oncol Case Report BACKGROUND: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. CASE REPORT: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life. CONCLUSIONS: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options. Versita, Warsaw 2013-10-08 /pmc/articles/PMC3814281/ /pubmed/24294181 http://dx.doi.org/10.2478/raon-2013-0059 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Case Report
Scelsi, Daniele
Mevio, Niccolò
Bertino, Giulia
Occhini, Antonio
Brazzelli, Valeria
Morbini, Patrizia
Benazzo, Marco
Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title_full Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title_fullStr Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title_full_unstemmed Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title_short Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region
title_sort electrochemotherapy as a new therapeutic strategy in advanced merkel cell carcinoma of head and neck region
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814281/
https://www.ncbi.nlm.nih.gov/pubmed/24294181
http://dx.doi.org/10.2478/raon-2013-0059
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