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Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood...

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Detalles Bibliográficos
Autores principales:	Murfuni, Ivana, Basile, Giorgia, Subramanyam, Shyamal, Malacaria, Eva, Bignami, Margherita, Spies, Maria, Franchitto, Annapaola, Pichierri, Pietro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814295/ https://www.ncbi.nlm.nih.gov/pubmed/24204313 http://dx.doi.org/10.1371/journal.pgen.1003910

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