Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway

Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a mutation in one of the mismatch repair genes ML...

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Detalles Bibliográficos
Autores principales: Smith, Catherine E., Mendillo, Marc L., Bowen, Nikki, Hombauer, Hans, Campbell, Christopher S., Desai, Arshad, Putnam, Christopher D., Kolodner, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814310/
https://www.ncbi.nlm.nih.gov/pubmed/24204293
http://dx.doi.org/10.1371/journal.pgen.1003869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814310/
https://www.ncbi.nlm.nih.gov/pubmed/24204293
http://dx.doi.org/10.1371/journal.pgen.1003869

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