The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can regenerate and convert into insulin-producing β-like cells through the ectopic expression of a single gene, Pax4. Here, combining conditional loss-of-function and lineage tracing approaches, we show that the selectiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Courtney, Monica, Gjernes, Elisabet, Druelle, Noémie, Ravaud, Christophe, Vieira, Andhira, Ben-Othman, Nouha, Pfeifer, Anja, Avolio, Fabio, Leuckx, Gunter, Lacas-Gervais, Sandra, Burel-Vandenbos, Fanny, Ambrosetti, Damien, Hecksher-Sorensen, Jacob, Ravassard, Philippe, Heimberg, Harry, Mansouri, Ahmed, Collombat, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814322/
https://www.ncbi.nlm.nih.gov/pubmed/24204325
http://dx.doi.org/10.1371/journal.pgen.1003934

Ejemplares similares

Ejemplares similares