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Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases

Antibacterial fluoroquinolones trap a cleavage complex of gyrase and topoisomerase (topo) IV inducing site-specific DNA breakage within a bent DNA gate engaged in DNA transport. Despite its importance for drug action and in revealing potential sites of topoisomerase catalysis, the mechanism of DNA s...

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Detalles Bibliográficos
Autores principales:	Arnoldi, Elisa, Pan, Xiao-Su, Fisher, L Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814380/ https://www.ncbi.nlm.nih.gov/pubmed/23939623 http://dx.doi.org/10.1093/nar/gkt696

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