CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

The ability to precisely modify endogenous genes can significantly facilitate biological studies and disease treatment, and the clustered regularly interspaced short palindromic repeats (CRISPR) systems have the potential to be powerful tools for genome engineering. However, the target specificity o...

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Detalles Bibliográficos
Autores principales: Cradick, Thomas J., Fine, Eli J., Antico, Christopher J., Bao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814385/
https://www.ncbi.nlm.nih.gov/pubmed/23939622
http://dx.doi.org/10.1093/nar/gkt714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814385/
https://www.ncbi.nlm.nih.gov/pubmed/23939622
http://dx.doi.org/10.1093/nar/gkt714

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