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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
The ability to precisely modify endogenous genes can significantly facilitate biological studies and disease treatment, and the clustered regularly interspaced short palindromic repeats (CRISPR) systems have the potential to be powerful tools for genome engineering. However, the target specificity o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814385/ https://www.ncbi.nlm.nih.gov/pubmed/23939622 http://dx.doi.org/10.1093/nar/gkt714 |