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Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions
Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814597/ https://www.ncbi.nlm.nih.gov/pubmed/24100888 http://dx.doi.org/10.3390/v5102447 |
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author | Eifan, Saleh Schnettler, Esther Dietrich, Isabelle Kohl, Alain Blomström, Anne-Lie |
author_facet | Eifan, Saleh Schnettler, Esther Dietrich, Isabelle Kohl, Alain Blomström, Anne-Lie |
author_sort | Eifan, Saleh |
collection | PubMed |
description | Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod. |
format | Online Article Text |
id | pubmed-3814597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38145972013-11-01 Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions Eifan, Saleh Schnettler, Esther Dietrich, Isabelle Kohl, Alain Blomström, Anne-Lie Viruses Review Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod. MDPI 2013-10-04 /pmc/articles/PMC3814597/ /pubmed/24100888 http://dx.doi.org/10.3390/v5102447 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Eifan, Saleh Schnettler, Esther Dietrich, Isabelle Kohl, Alain Blomström, Anne-Lie Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title | Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title_full | Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title_fullStr | Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title_full_unstemmed | Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title_short | Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions |
title_sort | non-structural proteins of arthropod-borne bunyaviruses: roles and functions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814597/ https://www.ncbi.nlm.nih.gov/pubmed/24100888 http://dx.doi.org/10.3390/v5102447 |
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