Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1

The RNPC1 RNA-binding protein, also called Rbm38, is a target of p53 and a repressor of p53 mRNA translation. Thus, the p53–RNPC1 loop is critical for modulating p53 tumor suppression, but it is not clear how the loop is regulated. Here, we showed that RNPC1 is phosphorylated at Ser195 by glycogen s...

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Detalles Bibliográficos
Autores principales: Zhang, Min, Zhang, Jin, Chen, Xiangling, Cho, Seong-Jun, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814645/
https://www.ncbi.nlm.nih.gov/pubmed/24142875
http://dx.doi.org/10.1101/gad.221739.113

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