RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

The ATR–CHK1 axis stabilizes stalled replication forks and prevents their collapse into DNA double-strand breaks (DSBs). Here, we show that fork collapse in Atr-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA–PLK1 pathway....

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Detalles Bibliográficos
Autores principales: Ragland, Ryan L., Patel, Sima, Rivard, Rebecca S., Smith, Kevin, Peters, Ashley A., Bielinsky, Anja-Katrin, Brown, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814646/
https://www.ncbi.nlm.nih.gov/pubmed/24142876
http://dx.doi.org/10.1101/gad.223180.113

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