N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling

The K(+):Cl(−) cotransporter (KCC) activity is modulated by phosphorylation/dephosphorylation processes. In isotonic conditions, KCCs are inactive and phosphorylated, whereas hypotonicity promotes their dephosphorylation and activation. Two phosphorylation sites (Thr-991 and Thr-1048) in KCC3 have b...

Descripción completa

Detalles Bibliográficos
Autores principales: Melo, Zesergio, de los Heros, Paola, Cruz-Rangel, Silvia, Vázquez, Norma, Bobadilla, Norma A., Pasantes-Morales, Herminia, Alessi, Dario R., Mercado, Adriana, Gamba, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814743/
https://www.ncbi.nlm.nih.gov/pubmed/24043619
http://dx.doi.org/10.1074/jbc.M113.475574

Ejemplares similares

Ejemplares similares