Cargando…

Mutagenic Analysis of the Intracellular Portals of the Human 5-HT(3)A Receptor

Structural models of Cys-loop receptors based on homology with the Torpedo marmorata nicotinic acetylcholine receptor infer the existence of cytoplasmic portals within the conduction pathway framed by helical amphipathic regions (termed membrane-associated (MA) helices) of adjacent intracellular M3-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carland, Jane E., Cooper, Michelle A., Livesey, Matthew R., Hales, Tim G., Peters, John A., Lambert, Jeremy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814755/ https://www.ncbi.nlm.nih.gov/pubmed/24030822 http://dx.doi.org/10.1074/jbc.M113.503300

Ejemplares similares

Structural Determinants of Ca(2+) Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor
por: Livesey, Matthew R., et al.
Publicado: (2008)

5-Hydroxytryptamine (5-HT) Cellular Sequestration during Chronic Exposure Delays 5-HT(3) Receptor Resensitization due to Its Subsequent Release
por: Hothersall, J. Daniel, et al.
Publicado: (2014)

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging
por: Montpas, Nicolas, et al.
Publicado: (2018)

Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor
por: Livesey, Matthew R., et al.
Publicado: (2011)

Dual Role of CO(2)/HCO(3)(−) Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths
por: Hulikova, Alzbeta, et al.
Publicado: (2011)

Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor
por: Windisch, Dirk, et al.
Publicado: (2015)

Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin–cubilin complex and transferrin receptor 1
por: Smith, Craig P., et al.
Publicado: (2019)

Tryptophan in the Pore of the Mechanosensitive Channel MscS: ASSESSMENT OF PORE CONFORMATIONS BY FLUORESCENCE SPECTROSCOPY
por: Rasmussen, Tim, et al.
Publicado: (2010)

The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel
por: Woo, Seung Kyoon, et al.
Publicado: (2013)

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
por: Gromek, Katarzyna A., et al.
Publicado: (2014)

Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
por: Botta, Joaquín, et al.
Publicado: (2019)

Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7)
por: Valinsky, William C., et al.
Publicado: (2016)

Structure Prediction of the Second Extracellular Loop in G-Protein-Coupled Receptors
por: Kmiecik, Sebastian, et al.
Publicado: (2014)

Ectodomain Movements of an ATP-gated Ion Channel (P2X2 Receptor) Probed by Disulfide Locking
por: Stelmashenko, Olga, et al.
Publicado: (2014)

Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization
por: Robinson, Lucy E., et al.
Publicado: (2014)

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP(3) Signaling
por: Buckles, Thomas C., et al.
Publicado: (2017)

Neuritin Activates Insulin Receptor Pathway to Up-regulate Kv4.2-mediated Transient Outward K(+) Current in Rat Cerebellar Granule Neurons
por: Yao, Jin-Jing, et al.
Publicado: (2012)

A junctophilin-caveolin interaction enables efficient coupling between ryanodine receptors and BK(Ca) channels in the Ca(2+) microdomain of vascular smooth muscle
por: Saeki, Takanori, et al.
Publicado: (2019)

Dysregulated Zn(2+) homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca(2+) leakage
por: Reilly-O'Donnell, Benedict, et al.
Publicado: (2017)

Solvent accessibility changes in a Na(+)-dependent C(4)-dicarboxylate transporter suggest differential substrate effects in a multistep mechanism
por: Sampson, Connor D.D., et al.
Publicado: (2021)

Calcium Promotes the Formation of Syntaxin 1 Mesoscale Domains through Phosphatidylinositol 4,5-Bisphosphate
por: Milovanovic, Dragomir, et al.
Publicado: (2016)

Vesicle Adhesion and Fusion Studied by Small-Angle X-Ray Scattering
por: Komorowski, Karlo, et al.
Publicado: (2018)

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes
por: Naylor, Jacqueline, et al.
Publicado: (2011)

Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release
por: Hatano, Noriyuki, et al.
Publicado: (2012)

Molecular Mechanism Underlying Phosphatidylinositol 4,5-Bisphosphate-induced Inhibition of SpIH Channels
por: Flynn, Galen E., et al.
Publicado: (2011)

Structural Determinants of Oligomerization of the Aquaporin-4 Channel
por: Kitchen, Philip, et al.
Publicado: (2016)

Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate–independent manner
por: Das, Anand Kant, et al.
Publicado: (2019)

Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker
por: Helliwell, Matthew V., et al.
Publicado: (2018)

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain
por: Lörinczi, Eva, et al.
Publicado: (2016)

Extracellular and Luminal pH Regulation by Vacuolar H(+)-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes
por: Smith, Gina A., et al.
Publicado: (2016)

The Oligomeric State and Arrangement of the Active Bacterial Translocon
por: Deville, Karine, et al.
Publicado: (2011)

WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters
por: Rinehart, Jesse, et al.
Publicado: (2011)

Structure and Function of the Bacterial Heterodimeric ABC Transporter CydDC: STIMULATION OF ATPASE ACTIVITY BY THIOL AND HEME COMPOUNDS
por: Yamashita, Masao, et al.
Publicado: (2014)

Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE
por: Caceres, Paulo S., et al.
Publicado: (2016)

Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar Type II Cells by Secretion of Angiopoietin-1
por: Fang, Xiaohui, et al.
Publicado: (2010)

AS160 Phosphotyrosine-binding Domain Constructs Inhibit Insulin-stimulated GLUT4 Vesicle Fusion with the Plasma Membrane
por: Koumanov, Françoise, et al.
Publicado: (2011)

Cortactin Controls Surface Expression of the Voltage-gated Potassium Channel K(V)10.1
por: Herrmann, Solveig, et al.
Publicado: (2012)

Simplified Bacterial “Pore” Channel Provides Insight into the Assembly, Stability, and Structure of Sodium Channels
por: McCusker, Emily C., et al.
Publicado: (2011)

β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece
por: Lin, Fu-Yang, et al.
Publicado: (2016)

Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2)
por: Gyimesi, Gergely, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gaa1k3ue69ihpp1unrrme6c8am