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The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing

Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replication. We show that Geminin preferentially forms stable coiled-coil heterodimers with its homologue, Idas. In cont...

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Detalles Bibliográficos
Autores principales:	Caillat, Christophe, Pefani, Dafni-Eleftheria, Gillespie, Peter J., Taraviras, Stavros, Blow, J. Julian, Lygerou, Zoi, Perrakis, Anastassis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814758/ https://www.ncbi.nlm.nih.gov/pubmed/24064211 http://dx.doi.org/10.1074/jbc.M113.491928

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