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Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

The ubiquitination of NEMO with linear ubiquitin chains by the E3-ligase LUBAC is important for the activation of the canonical NF-κB pathway. NEMO ubiquitination requires a dual target specificity of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiquitin....

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Detalles Bibliográficos
Autores principales:	Smit, Judith J., van Dijk, Willem J., El Atmioui, Dris, Merkx, Remco, Ovaa, Huib, Sixma, Titia K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814767/ https://www.ncbi.nlm.nih.gov/pubmed/24030825 http://dx.doi.org/10.1074/jbc.M113.495846

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