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DDX24 Negatively Regulates Cytosolic RNA-Mediated Innate Immune Signaling

RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, wh...

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Detalles Bibliográficos
Autores principales:	Ma, Zhe, Moore, Robert, Xu, Xiangxi, Barber, Glen N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814876/ https://www.ncbi.nlm.nih.gov/pubmed/24204270 http://dx.doi.org/10.1371/journal.ppat.1003721

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