Comparison of Mutation Patterns in Full-Genome A/H3N2 Influenza Sequences Obtained Directly from Clinical Samples and the Same Samples after a Single MDCK Passage

Human influenza viruses can be isolated efficiently from clinical samples using Madin-Darby canine kidney (MDCK) cells. However, this process is known to induce mutations in the virus as it adapts to this non-human cell-line. We performed a systematic study to record the pattern of MDCK-induced muta...

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Detalles Bibliográficos
Autores principales: Lee, Hong Kai, Tang, Julian Wei-Tze, Kong, Debra Han-Lin, Loh, Tze Ping, Chiang, Donald Kok-Leong, Lam, Tommy Tsan-Yuk, Koay, Evelyn Siew-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815150/
https://www.ncbi.nlm.nih.gov/pubmed/24223916
http://dx.doi.org/10.1371/journal.pone.0079252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815150/
https://www.ncbi.nlm.nih.gov/pubmed/24223916
http://dx.doi.org/10.1371/journal.pone.0079252

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