A Murine Model of Variant Late Infantile Ceroid Lipofuscinosis Recapitulates Behavioral and Pathological Phenotypes of Human Disease

Neuronal ceroid lipofuscinoses (NCLs; also known collectively as Batten Disease) are a family of autosomal recessive lysosomal storage disorders. Mutations in as many as 13 genes give rise to ∼10 variants of NCL, all with overlapping clinical symptomatology including visual impairment, motor and cog...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Jeremy P., Magee, Helen, Wong, Andrew, Nelson, Tarah, Koch, Bettina, Cooper, Jonathan D., Weimer, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815212/
https://www.ncbi.nlm.nih.gov/pubmed/24223841
http://dx.doi.org/10.1371/journal.pone.0078694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815212/
https://www.ncbi.nlm.nih.gov/pubmed/24223841
http://dx.doi.org/10.1371/journal.pone.0078694

Ejemplares similares