Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis

Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) is a 140 kDa bi-functional enzyme involved in a coupled reaction, where the glutaminase active site produces ammonia that is subsequently utilized to convert FGAR to its corresponding amidine in an ATP assisted fashion. The structure of FGA...

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Detalles Bibliográficos
Autores principales: Tanwar, Ajay Singh, Goyal, Venuka Durani, Choudhary, Deepanshu, Panjikar, Santosh, Anand, Ruchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815217/
https://www.ncbi.nlm.nih.gov/pubmed/24223728
http://dx.doi.org/10.1371/journal.pone.0077781

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