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Design of therapeutic vaccines: hepatitis B as an example

Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a...

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Detalles Bibliográficos
Autores principales: Kutscher, Sarah, Bauer, Tanja, Dembek, Claudia, Sprinzl, Martin, Protzer, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815787/
https://www.ncbi.nlm.nih.gov/pubmed/21958338
http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x
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author Kutscher, Sarah
Bauer, Tanja
Dembek, Claudia
Sprinzl, Martin
Protzer, Ulrike
author_facet Kutscher, Sarah
Bauer, Tanja
Dembek, Claudia
Sprinzl, Martin
Protzer, Ulrike
author_sort Kutscher, Sarah
collection PubMed
description Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi‐specific and multifunctional T‐cell response against key viral antigens is a paradigm of therapeutic vaccination – besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example.
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spelling pubmed-38157872014-02-12 Design of therapeutic vaccines: hepatitis B as an example Kutscher, Sarah Bauer, Tanja Dembek, Claudia Sprinzl, Martin Protzer, Ulrike Microb Biotechnol Research Articles Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi‐specific and multifunctional T‐cell response against key viral antigens is a paradigm of therapeutic vaccination – besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example. Blackwell Publishing Ltd 2012-03 2012-02-20 /pmc/articles/PMC3815787/ /pubmed/21958338 http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x Text en Copyright © 2011 The Authors. Microbial Biotechnology © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd
spellingShingle Research Articles
Kutscher, Sarah
Bauer, Tanja
Dembek, Claudia
Sprinzl, Martin
Protzer, Ulrike
Design of therapeutic vaccines: hepatitis B as an example
title Design of therapeutic vaccines: hepatitis B as an example
title_full Design of therapeutic vaccines: hepatitis B as an example
title_fullStr Design of therapeutic vaccines: hepatitis B as an example
title_full_unstemmed Design of therapeutic vaccines: hepatitis B as an example
title_short Design of therapeutic vaccines: hepatitis B as an example
title_sort design of therapeutic vaccines: hepatitis b as an example
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815787/
https://www.ncbi.nlm.nih.gov/pubmed/21958338
http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x
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