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Design of therapeutic vaccines: hepatitis B as an example
Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815787/ https://www.ncbi.nlm.nih.gov/pubmed/21958338 http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x |
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author | Kutscher, Sarah Bauer, Tanja Dembek, Claudia Sprinzl, Martin Protzer, Ulrike |
author_facet | Kutscher, Sarah Bauer, Tanja Dembek, Claudia Sprinzl, Martin Protzer, Ulrike |
author_sort | Kutscher, Sarah |
collection | PubMed |
description | Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi‐specific and multifunctional T‐cell response against key viral antigens is a paradigm of therapeutic vaccination – besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example. |
format | Online Article Text |
id | pubmed-3815787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38157872014-02-12 Design of therapeutic vaccines: hepatitis B as an example Kutscher, Sarah Bauer, Tanja Dembek, Claudia Sprinzl, Martin Protzer, Ulrike Microb Biotechnol Research Articles Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi‐specific and multifunctional T‐cell response against key viral antigens is a paradigm of therapeutic vaccination – besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example. Blackwell Publishing Ltd 2012-03 2012-02-20 /pmc/articles/PMC3815787/ /pubmed/21958338 http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x Text en Copyright © 2011 The Authors. Microbial Biotechnology © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd |
spellingShingle | Research Articles Kutscher, Sarah Bauer, Tanja Dembek, Claudia Sprinzl, Martin Protzer, Ulrike Design of therapeutic vaccines: hepatitis B as an example |
title | Design of therapeutic vaccines: hepatitis B as an example |
title_full | Design of therapeutic vaccines: hepatitis B as an example |
title_fullStr | Design of therapeutic vaccines: hepatitis B as an example |
title_full_unstemmed | Design of therapeutic vaccines: hepatitis B as an example |
title_short | Design of therapeutic vaccines: hepatitis B as an example |
title_sort | design of therapeutic vaccines: hepatitis b as an example |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815787/ https://www.ncbi.nlm.nih.gov/pubmed/21958338 http://dx.doi.org/10.1111/j.1751-7915.2011.00303.x |
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