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Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats
Objectives. Pharmacological and antifertility activity evaluation of Jatropha gossypifolia in rats. Methods. The antifertility activity of the extracts of Jatropha gossypifolia in rats was evaluated using two experimental animal models. Estrogenic activity was evaluated in immature female rats using...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816027/ https://www.ncbi.nlm.nih.gov/pubmed/24222894 http://dx.doi.org/10.1155/2013/125980 |
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author | Jain, Sachin Choudhary, Gajendra Pratap Jain, Dinesh Kumar |
author_facet | Jain, Sachin Choudhary, Gajendra Pratap Jain, Dinesh Kumar |
author_sort | Jain, Sachin |
collection | PubMed |
description | Objectives. Pharmacological and antifertility activity evaluation of Jatropha gossypifolia in rats. Methods. The antifertility activity of the extracts of Jatropha gossypifolia in rats was evaluated using two experimental animal models. Estrogenic activity was evaluated in immature female rats using ethinyl estradiol as standard. Anti-implantation and early abortifacient activity was performed in female Wistar rats by determining the number of implantations and implantation resorptions. Results. In estrogenic activity evaluations, the ethanolic and aqueous extracts offered significant estrogen-like activity at 400 mg kg(−1) p.o. by increasing the uterine weight compared to vehicle control group. Ethanolic extract (400 mg kg(−1), p.o.) treatment significantly decreased the number of implants and increased the number of resorptions compared to vehicle control group. Conclusion. The results of the present study provide the evidence of the anti-fertility activity of Jatropha gossypifolia as claimed in the traditional use. The results are consistent with the literature reports related to the antifertility effect of flower extracts of Jatropha gossypifolia. |
format | Online Article Text |
id | pubmed-3816027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38160272013-11-11 Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats Jain, Sachin Choudhary, Gajendra Pratap Jain, Dinesh Kumar Biomed Res Int Research Article Objectives. Pharmacological and antifertility activity evaluation of Jatropha gossypifolia in rats. Methods. The antifertility activity of the extracts of Jatropha gossypifolia in rats was evaluated using two experimental animal models. Estrogenic activity was evaluated in immature female rats using ethinyl estradiol as standard. Anti-implantation and early abortifacient activity was performed in female Wistar rats by determining the number of implantations and implantation resorptions. Results. In estrogenic activity evaluations, the ethanolic and aqueous extracts offered significant estrogen-like activity at 400 mg kg(−1) p.o. by increasing the uterine weight compared to vehicle control group. Ethanolic extract (400 mg kg(−1), p.o.) treatment significantly decreased the number of implants and increased the number of resorptions compared to vehicle control group. Conclusion. The results of the present study provide the evidence of the anti-fertility activity of Jatropha gossypifolia as claimed in the traditional use. The results are consistent with the literature reports related to the antifertility effect of flower extracts of Jatropha gossypifolia. Hindawi Publishing Corporation 2013 2013-10-08 /pmc/articles/PMC3816027/ /pubmed/24222894 http://dx.doi.org/10.1155/2013/125980 Text en Copyright © 2013 Sachin Jain et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jain, Sachin Choudhary, Gajendra Pratap Jain, Dinesh Kumar Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title | Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title_full | Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title_fullStr | Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title_full_unstemmed | Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title_short | Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats |
title_sort | pharmacological evaluation and antifertility activity of jatropha gossypifolia in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816027/ https://www.ncbi.nlm.nih.gov/pubmed/24222894 http://dx.doi.org/10.1155/2013/125980 |
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