Cargando…

Multimodality Molecular Imaging of Stem Cells Therapy for Stroke

Stem cells have been proposed as a promising therapy for treating stroke. While several studies have demonstrated the therapeutic benefits of stem cells, the exact mechanism remains elusive. Molecular imaging provides the possibility of the visual representation of biological processes at the cellul...

Descripción completa

Detalles Bibliográficos
Autores principales: Chao, Fangfang, Shen, Yehua, Zhang, Hong, Tian, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816035/
https://www.ncbi.nlm.nih.gov/pubmed/24222920
http://dx.doi.org/10.1155/2013/849819
_version_ 1782289481796157440
author Chao, Fangfang
Shen, Yehua
Zhang, Hong
Tian, Mei
author_facet Chao, Fangfang
Shen, Yehua
Zhang, Hong
Tian, Mei
author_sort Chao, Fangfang
collection PubMed
description Stem cells have been proposed as a promising therapy for treating stroke. While several studies have demonstrated the therapeutic benefits of stem cells, the exact mechanism remains elusive. Molecular imaging provides the possibility of the visual representation of biological processes at the cellular and molecular level. In order to facilitate research efforts to understand the stem cells therapeutic mechanisms, we need to further develop means of monitoring these cells noninvasively, longitudinally and repeatedly. Because of tissue depth and the blood-brain barrier (BBB), in vivo imaging of stem cells therapy for stroke has unique challenges. In this review, we describe existing methods of tracking transplanted stem cells in vivo, including magnetic resonance imaging (MRI), nuclear medicine imaging, and optical imaging (OI). Each of the imaging techniques has advantages and drawbacks. Finally, we describe multimodality imaging strategies as a more comprehensive and potential method to monitor transplanted stem cells for stroke.
format Online
Article
Text
id pubmed-3816035
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-38160352013-11-11 Multimodality Molecular Imaging of Stem Cells Therapy for Stroke Chao, Fangfang Shen, Yehua Zhang, Hong Tian, Mei Biomed Res Int Review Article Stem cells have been proposed as a promising therapy for treating stroke. While several studies have demonstrated the therapeutic benefits of stem cells, the exact mechanism remains elusive. Molecular imaging provides the possibility of the visual representation of biological processes at the cellular and molecular level. In order to facilitate research efforts to understand the stem cells therapeutic mechanisms, we need to further develop means of monitoring these cells noninvasively, longitudinally and repeatedly. Because of tissue depth and the blood-brain barrier (BBB), in vivo imaging of stem cells therapy for stroke has unique challenges. In this review, we describe existing methods of tracking transplanted stem cells in vivo, including magnetic resonance imaging (MRI), nuclear medicine imaging, and optical imaging (OI). Each of the imaging techniques has advantages and drawbacks. Finally, we describe multimodality imaging strategies as a more comprehensive and potential method to monitor transplanted stem cells for stroke. Hindawi Publishing Corporation 2013 2013-10-08 /pmc/articles/PMC3816035/ /pubmed/24222920 http://dx.doi.org/10.1155/2013/849819 Text en Copyright © 2013 Fangfang Chao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chao, Fangfang
Shen, Yehua
Zhang, Hong
Tian, Mei
Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title_full Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title_fullStr Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title_full_unstemmed Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title_short Multimodality Molecular Imaging of Stem Cells Therapy for Stroke
title_sort multimodality molecular imaging of stem cells therapy for stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816035/
https://www.ncbi.nlm.nih.gov/pubmed/24222920
http://dx.doi.org/10.1155/2013/849819
work_keys_str_mv AT chaofangfang multimodalitymolecularimagingofstemcellstherapyforstroke
AT shenyehua multimodalitymolecularimagingofstemcellstherapyforstroke
AT zhanghong multimodalitymolecularimagingofstemcellstherapyforstroke
AT tianmei multimodalitymolecularimagingofstemcellstherapyforstroke