The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods

The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an ind...

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Detalles Bibliográficos
Autores principales: Linka, Y, Ginzel, S, Krüger, M, Novosel, A, Gombert, M, Kremmer, E, Harbott, J, Thiele, R, Borkhardt, A, Landgraf, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816209/
https://www.ncbi.nlm.nih.gov/pubmed/24121163
http://dx.doi.org/10.1038/bcj.2013.48

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