Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo

Protooncogene T-cell leukemia 1 (TCL1), which is implicated in human T-cell prolymphocytic leukemia (T-PLL), interacts with Akt and enhances its kinase activity, functioning as an Akt kinase co-activator. Two major isoforms of TCL1 Protooncogenes (TCL1 and TCL1b) are present adjacent to each other o...

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Detalles Bibliográficos
Autores principales: Hashimoto, M, Suizu, F, Tokuyama, W, Noguchi, H, Hirata, N, Matsuda-Lennikov, M, Edamura, T, Masuzawa, M, Gotoh, N, Tanaka, S, Noguchi, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816220/
https://www.ncbi.nlm.nih.gov/pubmed/24042734
http://dx.doi.org/10.1038/oncsis.2013.30

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