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Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
BACKGROUND: Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816301/ https://www.ncbi.nlm.nih.gov/pubmed/24171759 http://dx.doi.org/10.1186/1744-9081-9-42 |
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author | Alosco, Michael L Brickman, Adam M Spitznagel, Mary Beth Griffith, Erica Y Narkhede, Atul Cohen, Ronald Sweet, Lawrence H Hughes, Joel Rosneck, Jim Gunstad, John |
author_facet | Alosco, Michael L Brickman, Adam M Spitznagel, Mary Beth Griffith, Erica Y Narkhede, Atul Cohen, Ronald Sweet, Lawrence H Hughes, Joel Rosneck, Jim Gunstad, John |
author_sort | Alosco, Michael L |
collection | PubMed |
description | BACKGROUND: Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF and a likely contributor to white matter hyperintensities (WMH). However, no study to date has examined the effects of cerebral blood flow, WMH, and brain volume on sleep quality in HF. METHODS: Fifty-three HF patients completed the Pittsburgh Sleep Quality Index and underwent brain magnetic resonance imaging to quantify brain and WMH volume. Transcranial Doppler ultrasonography assessed cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA). RESULTS: 75.5% of HF patients reported impaired sleep. Regression analyses adjusting for medical and demographic factors showed decreased CBF-V of the MCA and greater WMH volume were associated with poor sleep quality. No such pattern emerged on total brain or regional volume indices. CONCLUSIONS: Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples. |
format | Online Article Text |
id | pubmed-3816301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38163012013-11-04 Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure Alosco, Michael L Brickman, Adam M Spitznagel, Mary Beth Griffith, Erica Y Narkhede, Atul Cohen, Ronald Sweet, Lawrence H Hughes, Joel Rosneck, Jim Gunstad, John Behav Brain Funct Research BACKGROUND: Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF and a likely contributor to white matter hyperintensities (WMH). However, no study to date has examined the effects of cerebral blood flow, WMH, and brain volume on sleep quality in HF. METHODS: Fifty-three HF patients completed the Pittsburgh Sleep Quality Index and underwent brain magnetic resonance imaging to quantify brain and WMH volume. Transcranial Doppler ultrasonography assessed cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA). RESULTS: 75.5% of HF patients reported impaired sleep. Regression analyses adjusting for medical and demographic factors showed decreased CBF-V of the MCA and greater WMH volume were associated with poor sleep quality. No such pattern emerged on total brain or regional volume indices. CONCLUSIONS: Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples. BioMed Central 2013-10-30 /pmc/articles/PMC3816301/ /pubmed/24171759 http://dx.doi.org/10.1186/1744-9081-9-42 Text en Copyright © 2013 Alosco et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Alosco, Michael L Brickman, Adam M Spitznagel, Mary Beth Griffith, Erica Y Narkhede, Atul Cohen, Ronald Sweet, Lawrence H Hughes, Joel Rosneck, Jim Gunstad, John Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title | Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title_full | Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title_fullStr | Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title_full_unstemmed | Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title_short | Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
title_sort | reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816301/ https://www.ncbi.nlm.nih.gov/pubmed/24171759 http://dx.doi.org/10.1186/1744-9081-9-42 |
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