The first complete genome sequence of HCV-1a from Pakistan and a phylogenetic analysis with complete genomes from the rest of the world

BACKGROUND: Here, we report the first patient derived hepatitis C virus (HCV) complete genome from Pakistan as is not available from this region of the world. FINDINGS: Comprehensive evolutionary and phylogenetic analyses were conducted. The comparison was made in order to identify evolutionary and...

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Detalles Bibliográficos
Autores principales: Hussain, Abrar, Idrees, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816317/
https://www.ncbi.nlm.nih.gov/pubmed/23805872
http://dx.doi.org/10.1186/1743-422X-10-211
Descripción
Sumario:BACKGROUND: Here, we report the first patient derived hepatitis C virus (HCV) complete genome from Pakistan as is not available from this region of the world. FINDINGS: Comprehensive evolutionary and phylogenetic analyses were conducted. The comparison was made in order to identify evolutionary and molecular phylogenetic relationships among HCV strains belonging to genotype 1a. The evolutionary divergence analysis for nucleotide and amino acid sequences, conducted by equal input model, suggested that evolutionary nucleotide and amino acid distances showed that the HCV Pakistani strain was genetically far from Denmark strain (0.29400 nt, 0.819646 aa) and near to German strain (0.06557 nt, 0.139449 aa), respectively. CONCLUSION: The current study will help to understand phylogenetic relationship of circulating Pakistani isolates.

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