Cargando…

In vitro study of combined cilengitide and radiation treatment in breast cancer cell lines

BACKGROUND: Brain metastasis from breast cancer poses a major clinical challenge. Integrins play a role in regulating adhesion, growth, motility, and survival, and have been shown to be critical for metastatic growth in the brain in preclinical models. Cilengitide, an αvβ3/αvβ5 integrin inhibitor, h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lautenschlaeger, Tim, Perry, James, Peereboom, David, Li, Bin, Ibrahim, Ahmed, Huebner, Alexander, Meng, Wei, White, Julia, Chakravarti, Arnab
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816586/ https://www.ncbi.nlm.nih.gov/pubmed/24153102 http://dx.doi.org/10.1186/1748-717X-8-246

Ejemplares similares

Combined RASSF1A and RASSF2A Promoter Methylation Analysis as Diagnostic Biomarker for Bladder Cancer
por: Meng, Wei, et al.
Publicado: (2012)

In vitro and in vivo drug disposition of cilengitide in animals and human
por: Dolgos, Hugues, et al.
Publicado: (2016)

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome
por: Weller, Michael, et al.
Publicado: (2016)

Gene expression profiling of the anti-glioma effect of Cilengitide
por: Onishi, Manabu, et al.
Publicado: (2013)

SUN-LB054 Cilengitide Reverts Thyroid Hormones Effects in Bexarotene Treatment of Breast Cancer Cells
por: Díaz Albuja, Johanna, et al.
Publicado: (2019)

Comparison of MicroRNA Deep Sequencing of Matched Formalin-Fixed Paraffin-Embedded and Fresh Frozen Cancer Tissues
por: Meng, Wei, et al.
Publicado: (2013)

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
por: Mas-Moruno, Carlos, et al.
Publicado: (2010)

Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling
por: Zhu, Fawang, et al.
Publicado: (2021)

Very long-term survival of an older glioblastoma patient after treatment with cilengitide: a case report
por: Alalami, Huda, et al.
Publicado: (2023)

Cilengitide inhibits osteoclast adhesion through blocking the α(v)β(3)-mediated FAK/Src signaling pathway
por: Guo, Dan-yang, et al.
Publicado: (2023)

Combination Effect of Cilengitide with Erlotinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Human Non-Small Cell Lung Cancer Cells
por: Jeong, Jisu, et al.
Publicado: (2022)

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway
por: Oliveira-Ferrer, Leticia, et al.
Publicado: (2008)

Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis
por: Garciarena, Carolina D., et al.
Publicado: (2017)

Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer
por: Manegold, Christian, et al.
Publicado: (2012)

Reduced Cytokine Release in Ex Vivo Response to Cilengitide and Cetuximab Is a Marker for Improved Survival of Head and Neck Cancer Patients
por: Cedra, Susan, et al.
Publicado: (2017)

Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways
por: Meng, Wei, et al.
Publicado: (2022)

Lymphocyte Depletion Rate as a Biomarker of Radiation Dose to Circulating Lymphocytes During Fractionated Partial-Body Radiation Therapy
por: Ellsworth, Susannah G., et al.
Publicado: (2022)

The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells
por: Alghisi, Gian Carlo, et al.
Publicado: (2009)

Cilengitide Inhibits Attachment and Invasion of Malignant Pleural Mesothelioma Cells through Antagonism of Integrins αvβ3 and αvβ5
por: Cheng, Ngan Ching, et al.
Publicado: (2014)

Cilengitide-Induced Temporal Variations in Transvascular Transfer Parameters of Tumor Vasculature in a Rat Glioma Model: Identifying Potential MRI Biomarkers of Acute Effects
por: Nagaraja, Tavarekere N., et al.
Publicado: (2013)

Cilengitide, an αvβ3-integrin inhibitor, enhances the efficacy of anti-programmed cell death-1 therapy in a murine melanoma model
por: Pan, Xin, et al.
Publicado: (2022)

Effects of cilengitide derivatives on TGF-β1-induced epithelial-to-mesenchymal transition and invasion in gefitinib-resistant non-small cell lung cancer cells
por: Seo, Yujin, et al.
Publicado: (2023)

Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiation
por: Jacob, Naduparambil K, et al.
Publicado: (2012)

A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
por: Friess, Helmut, et al.
Publicado: (2006)

Phase I/II trial of cilengitide with cetuximab, cisplatin and 5-fluorouracil in recurrent and/or metastatic squamous cell cancer of the head and neck: findings of the phase I part
por: Vermorken, J B, et al.
Publicado: (2011)

TRLS-09. RTOG1119: PHASE II RANDOMIZED STUDY OF WHOLE BRAIN RADIOTHERAPY / STEREOTACTIC RADIOSURGERY IN COMBINATION WITH CONCURRENT LAPATINIB IN PATIENTS WITH BRAIN METASTASIS FROM HER2-POSITIVE BREAST CANCER
por: Kim, In Ah, et al.
Publicado: (2019)

Cyclic RGD Pentapeptide Cilengitide Enhances Efficacy of Gefitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Invasion in Human Non-Small Cell Lung Cancer Cells
por: Jeong, Jisu, et al.
Publicado: (2021)

Radiation Enhancer Effect of Platinum Nanoparticles in Breast Cancer Cell Lines: In Vitro and In Silico Analyses
por: Hullo, Marie, et al.
Publicado: (2021)

Improving Intra-Fractional Target Position Accuracy Using a 3D Surface Surrogate for Left Breast Irradiation Using the Respiratory-Gated Deep-Inspiration Breath-Hold Technique
por: Rong, Yi, et al.
Publicado: (2014)

Synchronous Supraglottic and Esophageal Squamous Cell Carcinomas Treated with a Monoisocentric Hybrid Intensity-Modulated Radiation Technique
por: Barney, Christian L., et al.
Publicado: (2018)

Preliminary Approach to Implementing a COVID-19 Thoracic Radiation Therapy Program
por: Saripalli, Anjali L., et al.
Publicado: (2022)

Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of the head and neck: results of the randomized phase I/II ADVANTAGE trial (phase II part)
por: Vermorken, J. B., et al.
Publicado: (2014)

Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma
por: Bassett, Emily A., et al.
Publicado: (2018)

Novel Therapies in Glioblastoma
por: Perry, James, et al.
Publicado: (2012)

Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry
por: Jacob, Naduparambil Korah, et al.
Publicado: (2013)

Inter-Fraction Tumor Volume Response during Lung Stereotactic Body Radiation Therapy Correlated to Patient Variables
por: Salamekh, Samer, et al.
Publicado: (2016)

Diagnostic and Prognostic Significance of Methionine Uptake and Methionine Positron Emission Tomography Imaging in Gliomas
por: Palanichamy, Kamalakannan, et al.
Publicado: (2017)

In Vitro Evaluation of ALDH1A3-Affinic Compounds on Breast and Prostate Cancer Cell Lines as Single Treatments and in Combination with Doxorubicin
por: Abusara, Osama H., et al.
Publicado: (2023)

Low-dose whole thorax radiation therapy for COVID-19 pneumonia: inpatient onboarding process for a randomized controlled trial
por: McClelland, Shearwood, et al.
Publicado: (2021)

Plasma‐based biomaterials for the treatment of cutaneous radiation injury
por: Miller, Eric D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jeej8v2tco7g0huc0l0bsoac8g