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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816642/ https://www.ncbi.nlm.nih.gov/pubmed/24280700 http://dx.doi.org/10.3390/ph5090963 |
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author | Lizcano, Fernando Garcia, Jeison |
author_facet | Lizcano, Fernando Garcia, Jeison |
author_sort | Lizcano, Fernando |
collection | PubMed |
description | The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript. |
format | Online Article Text |
id | pubmed-3816642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38166422013-11-14 Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets Lizcano, Fernando Garcia, Jeison Pharmaceuticals (Basel) Review The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript. MDPI 2012-09-12 /pmc/articles/PMC3816642/ /pubmed/24280700 http://dx.doi.org/10.3390/ph5090963 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Lizcano, Fernando Garcia, Jeison Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title | Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title_full | Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title_fullStr | Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title_full_unstemmed | Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title_short | Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets |
title_sort | epigenetic control and cancer: the potential of histone demethylases as therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816642/ https://www.ncbi.nlm.nih.gov/pubmed/24280700 http://dx.doi.org/10.3390/ph5090963 |
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