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Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the trea...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816645/ https://www.ncbi.nlm.nih.gov/pubmed/24280701 http://dx.doi.org/10.3390/ph5090991 |
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author | Regberg, Jakob Srimanee, Artita Langel, Ülo |
author_facet | Regberg, Jakob Srimanee, Artita Langel, Ülo |
author_sort | Regberg, Jakob |
collection | PubMed |
description | Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides. |
format | Online Article Text |
id | pubmed-3816645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38166452013-11-14 Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies Regberg, Jakob Srimanee, Artita Langel, Ülo Pharmaceuticals (Basel) Review Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides. MDPI 2012-09-12 /pmc/articles/PMC3816645/ /pubmed/24280701 http://dx.doi.org/10.3390/ph5090991 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Regberg, Jakob Srimanee, Artita Langel, Ülo Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title | Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title_full | Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title_fullStr | Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title_full_unstemmed | Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title_short | Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies |
title_sort | applications of cell-penetrating peptides for tumor targeting and future cancer therapies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816645/ https://www.ncbi.nlm.nih.gov/pubmed/24280701 http://dx.doi.org/10.3390/ph5090991 |
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