Design, Synthesis and Hydrolytic Behavior of Mutual Prodrugs of NSAIDs with Gabapentin Using Glycol Spacers

The free –COOH present in NSAIDs is thought to be responsible for the GI irritation associated with all traditional NSAIDs. Exploitation of mutual prodrugs is an approach wherein the NSAID is covalently bounded to a second pharmacologically active carrier/drug with the ultimate aim of reducing the g...

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Detalles Bibliográficos
Autores principales: Mahdi, Monther Faisal, Alsaad, Hiba Najeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816658/
https://www.ncbi.nlm.nih.gov/pubmed/24281258
http://dx.doi.org/10.3390/ph5101080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816658/
https://www.ncbi.nlm.nih.gov/pubmed/24281258
http://dx.doi.org/10.3390/ph5101080

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