Cargando…

Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamideand Its Analogs

Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed on t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hayun, Hudiyono, Sumi, Hanafi, Muhammad, Yanuar, Arry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816667/ https://www.ncbi.nlm.nih.gov/pubmed/24281337 http://dx.doi.org/10.3390/ph5121282

Ejemplares similares

Virtual screening of 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety for COX-2 inhibitor
por: Hayun,, et al.
Publicado: (2011)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl 4-bromobenzene-1-sulfonate
por: El-Azab, Adel S., et al.
Publicado: (2012)

3,8-Dimethyl-4-oxo-3,4-dihydroquinazoline-6-carbonitrile
por: Tian, Hai-Yan, et al.
Publicado: (2012)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl benzoate
por: El-Azab, Adel S., et al.
Publicado: (2012)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl 4-methylbenzoate
por: El-Azab, Adel S., et al.
Publicado: (2012)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl 4-chlorobenzoate
por: El-Azab, Adel S., et al.
Publicado: (2012)

2-{[2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl]oxy}acetonitrile
por: El-Azab, Adel S., et al.
Publicado: (2012)

3-Amino-2-methyl-4-oxo-3,4-dihydroquinazolin-1-ium p-toluenesulfonate monohydrate
por: Arfan, Mohammad, et al.
Publicado: (2009)

2-Methyl-4-phenyl-3,4-dihydroquinazoline
por: Valkonen, Arto, et al.
Publicado: (2011)

Crystal structure of 3-benzyl-2-[(E)-2-(furan-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one and 3-benzyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one from synchrotron X-ray diffraction
por: Toze, Flavien A. A., et al.
Publicado: (2018)

Synthesis and structure of ethyl 2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]acetate
por: Nguyen Tien, Cong, et al.
Publicado: (2020)

2-[2-(2-Anilino-4-oxo-3,4-dihydroquinazolin-3-yl)phenoxy]-3-phenylquinazolin-4(3H)-one methanol hemisolvate
por: Gao, Tao, et al.
Publicado: (2010)

1-Ethenyl-4-[(phenylsulfanyl)methyl]benzene
por: Avila-Sorrosa, Alcives, et al.
Publicado: (2012)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl thiophene-2-carboxylate
por: El-Azab, Adel S., et al.
Publicado: (2012)

2-Chloro-N-(2-chlorobenzoyl)-N-(2-ethyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzamide
por: Bakare, Oladapo, et al.
Publicado: (2014)

Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine
por: Díaz, Jimena E, et al.
Publicado: (2017)

Methyl 3-[(6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]propanoate
por: Al-Suwaidan, Ibrahim A., et al.
Publicado: (2013)

5-[2-(4-Acetyloxyphenyl)ethenyl]benzene-1,3-diyl diacetate
por: Tang, Lin, et al.
Publicado: (2011)

7-Benzenesulfonamido-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid methanol solvate
por: Mariam, Irfana, et al.
Publicado: (2009)

Crystal structure of 4,4-dibutyl-2-phenyl-3,4-dihydroquinazoline
por: El-Hiti, Gamal A., et al.
Publicado: (2014)

Crystal structure and Hirshfeld surface analysis of 3-methyl-4-oxo-N-phenyl-3,4-dihydroquinazoline-2-carbothioamide
por: Pirnazarova, Nasiba, et al.
Publicado: (2022)

N-(4-Acetyl-3-methyl-1-phenyl-1H-pyrazol-5-yl)-N-methyl-2-(2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzamide
por: Meneghetti, Fiorella, et al.
Publicado: (2013)

Ethyl 4′-ethenyl-2′-oxo-4-phenyl-2-(3,4,5-trimethoxyphenyl)spiro[pyrrolidine-3,3′-indoline]-5-carboxylate monohydrate
por: Sathyanarayanan, M., et al.
Publicado: (2008)

1-Methyl-4-[(E)-2-(2-thienyl)ethenyl]pyridinium 4-methylbenzenesulfonate
por: Chantrapromma, Suchada, et al.
Publicado: (2008)

1-Methyl-4-[(E)-2-(2-thienyl)ethenyl]pyridinium 4-chlorobenzenesulfonate
por: Chantrapromma, Suchada, et al.
Publicado: (2008)

1-Ethoxy-2-methoxy-4-[2-(4-nitrophenyl)ethenyl]benzene
por: Dinakaran, Paul M., et al.
Publicado: (2012)

2-(2-{[4-Oxo-3-(2-phenylethyl)-3,4-dihydroquinazolin-2-yl]sulfanyl}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione
por: El-Azab, Adel S., et al.
Publicado: (2012)

1-[2,2-Bis(phenylsulfonyl)ethenyl]-4-methoxybenzene
por: Asahara, Haruyasu, et al.
Publicado: (2012)

4-{2-[4-(Dimethylamino)phenyl]ethenyl}-1-methylpyridinium 4-nitrobenzenesulfonate
por: Li, Liang, et al.
Publicado: (2012)

2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methylpyridinium 4-bromobenzenesulfonate
por: Chantrapromma, Suchada, et al.
Publicado: (2009)

2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methylpyridinium 4-chlorobenzenesulfonate
por: Fun, Hoong-Kun, et al.
Publicado: (2009)

2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methylpyridinium 4-methoxybenzenesulfonate
por: Chanawanno, Kullapa, et al.
Publicado: (2009)

2-Methyl-2-phenyl-1,2-dihydroquinazolin-4(3H)-one
por: Zhang, Lijun, et al.
Publicado: (2008)

2,2,7-Trimethyl-2,3-dihydroquinazolin-4(1H)-one
por: Zhang, Ling, et al.
Publicado: (2009)

4-{2-[4-(Dimethylamino)phenyl]ethenyl}-1-methylpyridinium 2-amino-3,5-dimethylbenzenesulfonate monohydrate
por: Li, Liang, et al.
Publicado: (2012)

2-[(E)-2-(4-Hydroxy-3-methoxyphenyl)ethenyl]-1-methylpyridinium 4-bromobenzenesulfonate monohydrate
por: Chantrapromma, Suchada, et al.
Publicado: (2013)

2-[(E)-2-(1H-Indol-3-yl)ethenyl]-1-methylpyridinium 4-chlorobenzenesulfonate
por: Kobkeatthawin, Thawanrat, et al.
Publicado: (2009)

2-[(E)-2-(1H-Indol-3-yl)ethenyl]-1-methylpyridinium 4-bromobenzenesulfonate
por: Chantrapromma, Suchada, et al.
Publicado: (2009)

(S)-2-(3-Nitrophenyl)-1,2-dihydroquinazolin-4(3H)-one
por: Zhang, Lijun, et al.
Publicado: (2008)

2-[(E)-2-(4-Ethoxyphenyl)ethenyl]-1-methylpyridinium 4-bromobenzenesulfonate monohydrate
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_653trm8khqb2jmttkjr9s2n3jk