The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin a...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Huayun, Fang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816702/
https://www.ncbi.nlm.nih.gov/pubmed/24276120
http://dx.doi.org/10.3390/ph6040500
_version_ 1782477975923458048
author Deng, Huayun
Fang, Ye
author_facet Deng, Huayun
Fang, Ye
author_sort Deng, Huayun
collection PubMed
description Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
format Online
Article
Text
id pubmed-3816702
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-38167022013-11-14 The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists Deng, Huayun Fang, Ye Pharmaceuticals (Basel) Article Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35. MDPI 2013-04-08 /pmc/articles/PMC3816702/ /pubmed/24276120 http://dx.doi.org/10.3390/ph6040500 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Deng, Huayun
Fang, Ye
The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title_full The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title_fullStr The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title_full_unstemmed The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title_short The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
title_sort three catecholics benserazide, catechol and pyrogallol are gpr35 agonists
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816702/
https://www.ncbi.nlm.nih.gov/pubmed/24276120
http://dx.doi.org/10.3390/ph6040500
work_keys_str_mv AT denghuayun thethreecatecholicsbenserazidecatecholandpyrogallolaregpr35agonists
AT fangye thethreecatecholicsbenserazidecatecholandpyrogallolaregpr35agonists
AT denghuayun threecatecholicsbenserazidecatecholandpyrogallolaregpr35agonists
AT fangye threecatecholicsbenserazidecatecholandpyrogallolaregpr35agonists

Ejemplares similares