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Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin
Reviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816705/ https://www.ncbi.nlm.nih.gov/pubmed/24276319 http://dx.doi.org/10.3390/ph6070867 |
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author | Scurtu, Violeta-Florina Moţ, Augustin C. Silaghi-Dumitrescu, Radu |
author_facet | Scurtu, Violeta-Florina Moţ, Augustin C. Silaghi-Dumitrescu, Radu |
author_sort | Scurtu, Violeta-Florina |
collection | PubMed |
description | Reviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the extent to which these modifications alter the redox reactivity of the proteins, and on ways in which this can be done systematically and purposefully, within the framework of a working hypothesis where redox side-reactions hold an important role in the physiological outcome of experimental transfusions with artificial oxygen carriers. |
format | Online Article Text |
id | pubmed-3816705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38167052013-11-14 Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin Scurtu, Violeta-Florina Moţ, Augustin C. Silaghi-Dumitrescu, Radu Pharmaceuticals (Basel) Review Reviewed here are recent attempts to produce protein-based artificial oxygen carriers (“blood substitutes”). Most of these involve chemical or physical modifications on hemoglobin, although a recent line of research using hemerythrin instead of hemoglobin is also described. The focus is set on the extent to which these modifications alter the redox reactivity of the proteins, and on ways in which this can be done systematically and purposefully, within the framework of a working hypothesis where redox side-reactions hold an important role in the physiological outcome of experimental transfusions with artificial oxygen carriers. MDPI 2013-07-04 /pmc/articles/PMC3816705/ /pubmed/24276319 http://dx.doi.org/10.3390/ph6070867 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Scurtu, Violeta-Florina Moţ, Augustin C. Silaghi-Dumitrescu, Radu Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title | Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title_full | Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title_fullStr | Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title_full_unstemmed | Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title_short | Protein-Based Blood Substitutes: Recent Attempts at Controlling Pro-Oxidant Reactivity With and Beyond Hemoglobin |
title_sort | protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816705/ https://www.ncbi.nlm.nih.gov/pubmed/24276319 http://dx.doi.org/10.3390/ph6070867 |
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