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Control of gene expression by CRISPR-Cas systems
Clustered regularly interspaced short palindromic repeats (CRISPR) loci and their associated cas (CRISPR-associated) genes provide adaptive immunity against viruses (phages) and other mobile genetic elements in bacteria and archaea. While most of the early work has largely been dominated by examples...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816762/ https://www.ncbi.nlm.nih.gov/pubmed/24273648 http://dx.doi.org/10.12703/P5-47 |
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author | Bikard, David Marraffini, Luciano A. |
author_facet | Bikard, David Marraffini, Luciano A. |
author_sort | Bikard, David |
collection | PubMed |
description | Clustered regularly interspaced short palindromic repeats (CRISPR) loci and their associated cas (CRISPR-associated) genes provide adaptive immunity against viruses (phages) and other mobile genetic elements in bacteria and archaea. While most of the early work has largely been dominated by examples of CRISPR-Cas systems directing the cleavage of phage or plasmid DNA, recent studies have revealed a more complex landscape where CRISPR-Cas loci might be involved in gene regulation. In this review, we summarize the role of these loci in the regulation of gene expression as well as the recent development of synthetic gene regulation using engineered CRISPR-Cas systems. |
format | Online Article Text |
id | pubmed-3816762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38167622013-11-22 Control of gene expression by CRISPR-Cas systems Bikard, David Marraffini, Luciano A. F1000Prime Rep Review Article Clustered regularly interspaced short palindromic repeats (CRISPR) loci and their associated cas (CRISPR-associated) genes provide adaptive immunity against viruses (phages) and other mobile genetic elements in bacteria and archaea. While most of the early work has largely been dominated by examples of CRISPR-Cas systems directing the cleavage of phage or plasmid DNA, recent studies have revealed a more complex landscape where CRISPR-Cas loci might be involved in gene regulation. In this review, we summarize the role of these loci in the regulation of gene expression as well as the recent development of synthetic gene regulation using engineered CRISPR-Cas systems. Faculty of 1000 Ltd 2013-11-01 /pmc/articles/PMC3816762/ /pubmed/24273648 http://dx.doi.org/10.12703/P5-47 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Bikard, David Marraffini, Luciano A. Control of gene expression by CRISPR-Cas systems |
title | Control of gene expression by CRISPR-Cas systems |
title_full | Control of gene expression by CRISPR-Cas systems |
title_fullStr | Control of gene expression by CRISPR-Cas systems |
title_full_unstemmed | Control of gene expression by CRISPR-Cas systems |
title_short | Control of gene expression by CRISPR-Cas systems |
title_sort | control of gene expression by crispr-cas systems |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816762/ https://www.ncbi.nlm.nih.gov/pubmed/24273648 http://dx.doi.org/10.12703/P5-47 |
work_keys_str_mv | AT bikarddavid controlofgeneexpressionbycrisprcassystems AT marraffinilucianoa controlofgeneexpressionbycrisprcassystems |