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The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?

Ulcerative colitis and Crohn's disease together are known as inflammatory bowel disease (IBD). Surgery is considered for more severe disease and is a dreaded consequence for patients. Thiopurines have proven efficacy in the induction and maintenance of remission of IBD, but the long-term need f...

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Detalles Bibliográficos
Autores principales: Chhaya, Vivek, Pollok, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816845/
https://www.ncbi.nlm.nih.gov/pubmed/24273651
http://dx.doi.org/10.12703/P5-50
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author Chhaya, Vivek
Pollok, Richard
author_facet Chhaya, Vivek
Pollok, Richard
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description Ulcerative colitis and Crohn's disease together are known as inflammatory bowel disease (IBD). Surgery is considered for more severe disease and is a dreaded consequence for patients. Thiopurines have proven efficacy in the induction and maintenance of remission of IBD, but the long-term need for surgery remains uncertain with conflicting results from the available studies. The timing and duration of thiopurines also appears to play a pivotal role in the management of these conditions and may also affect the need for surgery. Data from Denmark, Canada, Hungary and the UK appear to suggest a reduction in surgery rates prior to the introduction of anti-tumor necrosis factor (TNF) therapy. The authors aim to review the more recent literature evaluating the surgery rates in IBD and changes in disease trends over time. We ask whether increasing thiopurine prescribing has had an effect on the surgery rates in the era of biologic therapy and whether more aggressive treatment approaches have altered the natural history of IBD.
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spelling pubmed-38168452013-11-22 The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference? Chhaya, Vivek Pollok, Richard F1000Prime Rep Review Article Ulcerative colitis and Crohn's disease together are known as inflammatory bowel disease (IBD). Surgery is considered for more severe disease and is a dreaded consequence for patients. Thiopurines have proven efficacy in the induction and maintenance of remission of IBD, but the long-term need for surgery remains uncertain with conflicting results from the available studies. The timing and duration of thiopurines also appears to play a pivotal role in the management of these conditions and may also affect the need for surgery. Data from Denmark, Canada, Hungary and the UK appear to suggest a reduction in surgery rates prior to the introduction of anti-tumor necrosis factor (TNF) therapy. The authors aim to review the more recent literature evaluating the surgery rates in IBD and changes in disease trends over time. We ask whether increasing thiopurine prescribing has had an effect on the surgery rates in the era of biologic therapy and whether more aggressive treatment approaches have altered the natural history of IBD. Faculty of 1000 Ltd 2013-11-01 /pmc/articles/PMC3816845/ /pubmed/24273651 http://dx.doi.org/10.12703/P5-50 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Chhaya, Vivek
Pollok, Richard
The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title_full The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title_fullStr The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title_full_unstemmed The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title_short The impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
title_sort impact of thiopurines on surgical outcomes in inflammatory bowel disease: do they make a difference?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816845/
https://www.ncbi.nlm.nih.gov/pubmed/24273651
http://dx.doi.org/10.12703/P5-50
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