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Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes
OBJECTIVE: Although oxidative stress (OxS) is thought to contribute to atherosclerosis and coronary artery disease (CAD), little is known about the variability in an individual’s ability to respond to OxS. Therefore, we assessed potential indices of response to OxS and evaluated whether they modify...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816903/ https://www.ncbi.nlm.nih.gov/pubmed/23920084 http://dx.doi.org/10.2337/dc12-2378 |
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author | Costacou, Tina Evans, Rhobert W. Schafer, Gerald L. Orchard, Trevor J. |
author_facet | Costacou, Tina Evans, Rhobert W. Schafer, Gerald L. Orchard, Trevor J. |
author_sort | Costacou, Tina |
collection | PubMed |
description | OBJECTIVE: Although oxidative stress (OxS) is thought to contribute to atherosclerosis and coronary artery disease (CAD), little is known about the variability in an individual’s ability to respond to OxS. Therefore, we assessed potential indices of response to OxS and evaluated whether they modify the association between OxS and CAD. RESEARCH DESIGN AND METHODS: We evaluated plasma α- and γ-tocopherol per unit cholesterol (potential response markers); urinary 15-isoprostane F(2t) per milligram creatinine (isoprostane [IsoP], a potential stress marker); and the α-tocopherol-to-IsoP ratio (as a measure of response to stress), measured three times during 20 years of follow-up, in relation to CAD incidence in a cohort with childhood-onset type 1 diabetes (n = 658; mean age at baseline, 28 years; duration of diabetes, 19 years). Participants with three samples (blood and either 24-h or overnight urine) available before the onset of CAD or the end of follow-up (n = 356) were selected for study. RESULTS: In multivariable mixed models, α-tocopherol over time was inversely associated with CAD (β = −0.27; P = 0.02), whereas a direct association was observed for IsoP (β = 0.0008; P = 0.06). Moreover, the α-tocopherol-to-IsoP ratio was strongly and inversely related to CAD incidence (β = −0.72; P = 0.003), whereas in a separate model including α-tocopherol and IsoP, both biomarkers maintained statistical significance. No association was observed for γ-tocopherol (β = −0.22; P = 0.54). CONCLUSIONS: These data suggest that a greater potential capability (α-tocopherol) to respond to OxS (urinary IsoP) relates to CAD incidence. |
format | Online Article Text |
id | pubmed-3816903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-38169032014-11-01 Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes Costacou, Tina Evans, Rhobert W. Schafer, Gerald L. Orchard, Trevor J. Diabetes Care Original Research OBJECTIVE: Although oxidative stress (OxS) is thought to contribute to atherosclerosis and coronary artery disease (CAD), little is known about the variability in an individual’s ability to respond to OxS. Therefore, we assessed potential indices of response to OxS and evaluated whether they modify the association between OxS and CAD. RESEARCH DESIGN AND METHODS: We evaluated plasma α- and γ-tocopherol per unit cholesterol (potential response markers); urinary 15-isoprostane F(2t) per milligram creatinine (isoprostane [IsoP], a potential stress marker); and the α-tocopherol-to-IsoP ratio (as a measure of response to stress), measured three times during 20 years of follow-up, in relation to CAD incidence in a cohort with childhood-onset type 1 diabetes (n = 658; mean age at baseline, 28 years; duration of diabetes, 19 years). Participants with three samples (blood and either 24-h or overnight urine) available before the onset of CAD or the end of follow-up (n = 356) were selected for study. RESULTS: In multivariable mixed models, α-tocopherol over time was inversely associated with CAD (β = −0.27; P = 0.02), whereas a direct association was observed for IsoP (β = 0.0008; P = 0.06). Moreover, the α-tocopherol-to-IsoP ratio was strongly and inversely related to CAD incidence (β = −0.72; P = 0.003), whereas in a separate model including α-tocopherol and IsoP, both biomarkers maintained statistical significance. No association was observed for γ-tocopherol (β = −0.22; P = 0.54). CONCLUSIONS: These data suggest that a greater potential capability (α-tocopherol) to respond to OxS (urinary IsoP) relates to CAD incidence. American Diabetes Association 2013-11 2013-10-15 /pmc/articles/PMC3816903/ /pubmed/23920084 http://dx.doi.org/10.2337/dc12-2378 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Costacou, Tina Evans, Rhobert W. Schafer, Gerald L. Orchard, Trevor J. Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title | Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title_full | Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title_fullStr | Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title_full_unstemmed | Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title_short | Oxidative Stress and Response in Relation to Coronary Artery Disease in Type 1 Diabetes |
title_sort | oxidative stress and response in relation to coronary artery disease in type 1 diabetes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816903/ https://www.ncbi.nlm.nih.gov/pubmed/23920084 http://dx.doi.org/10.2337/dc12-2378 |
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