Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hyperten...

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Detalles Bibliográficos
Autores principales: Hu, Ying, Tan, Hai Bo, Wang, Xin Mei, Rong, Hua, Cui, Hong Ping, Cui, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817004/
https://www.ncbi.nlm.nih.gov/pubmed/24204132
http://dx.doi.org/10.2147/CIA.S47350
Descripción
Sumario:Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

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