Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hyperten...

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Autores principales: Hu, Ying, Tan, Hai Bo, Wang, Xin Mei, Rong, Hua, Cui, Hong Ping, Cui, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817004/
https://www.ncbi.nlm.nih.gov/pubmed/24204132
http://dx.doi.org/10.2147/CIA.S47350
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author Hu, Ying
Tan, Hai Bo
Wang, Xin Mei
Rong, Hua
Cui, Hong Ping
Cui, Hao
author_facet Hu, Ying
Tan, Hai Bo
Wang, Xin Mei
Rong, Hua
Cui, Hong Ping
Cui, Hao
author_sort Hu, Ying
collection PubMed
description Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.
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spelling pubmed-38170042013-11-07 Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma Hu, Ying Tan, Hai Bo Wang, Xin Mei Rong, Hua Cui, Hong Ping Cui, Hao Clin Interv Aging Short Report Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma. Dove Medical Press 2013 2013-10-31 /pmc/articles/PMC3817004/ /pubmed/24204132 http://dx.doi.org/10.2147/CIA.S47350 Text en © 2013 Hu et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Short Report
Hu, Ying
Tan, Hai Bo
Wang, Xin Mei
Rong, Hua
Cui, Hong Ping
Cui, Hao
Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_fullStr Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full_unstemmed Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_short Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_sort bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817004/
https://www.ncbi.nlm.nih.gov/pubmed/24204132
http://dx.doi.org/10.2147/CIA.S47350
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