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Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe
Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis mainly transmitted by ticks that causes severe hemorrhagic fever and has a mortality rate of 5-60%. The first outbreak of CCHF occurred in the Crimean peninsula in 1944-45 and it has recently emerged in the Balkans and eastern Mediterranean. In or...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817137/ https://www.ncbi.nlm.nih.gov/pubmed/24223988 http://dx.doi.org/10.1371/journal.pone.0079663 |
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author | Zehender, Gianguglielmo Ebranati, Erika Shkjezi, Renata Papa, Anna Luzzago, Camilla Gabanelli, Elena Lo Presti, Alessandra Lai, Alessia Rezza, Giovanni Galli, Massimo Bino, Silvia Ciccozzi, Massimo |
author_facet | Zehender, Gianguglielmo Ebranati, Erika Shkjezi, Renata Papa, Anna Luzzago, Camilla Gabanelli, Elena Lo Presti, Alessandra Lai, Alessia Rezza, Giovanni Galli, Massimo Bino, Silvia Ciccozzi, Massimo |
author_sort | Zehender, Gianguglielmo |
collection | PubMed |
description | Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis mainly transmitted by ticks that causes severe hemorrhagic fever and has a mortality rate of 5-60%. The first outbreak of CCHF occurred in the Crimean peninsula in 1944-45 and it has recently emerged in the Balkans and eastern Mediterranean. In order to reconstruct the origin and pathway of the worldwide dispersion of the virus at global and regional (eastern European) level, we investigated the phylogeography of the infection by analysing 121 publicly available CCHFV S gene sequences including two recently characterised Albanian isolates. The spatial and temporal phylogeny was reconstructed using a Bayesian Markov chain Monte Carlo approach, which estimated a mean evolutionary rate of 2.96 x 10(-4) (95%HPD=1.6 and 4.7 x 10(-4)) substitutions/site/year for the analysed fragment. All of the isolates segregated into seven highly significant clades that correspond to the known geographical clades: in particular the two new isolates from northern Albania clustered significantly within the Europe 1 clade. Our phylogeographical reconstruction suggests that the global CCHFV clades originated about one thousand years ago from a common ancestor probably located in Africa. The virus then spread to Asia in the XV century and entered Europe on at least two occasions: the first in the early 1800s, when a still circulating but less or non-pathogenic virus emerged in Greece and Turkey, and the second in the early 1900s, when a pathogenic CCHFV strain began to spread in eastern Europe. The most probable location for the origin of this European clade 1 was Russia, but Turkey played a central role in spreading the virus throughout Europe. Given the close proximity of the infected areas, our data suggest that the movement of wild and domestic ungulates from endemic areas was probably the main cause of the dissemination of the virus in eastern Europe. |
format | Online Article Text |
id | pubmed-3817137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38171372013-11-09 Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe Zehender, Gianguglielmo Ebranati, Erika Shkjezi, Renata Papa, Anna Luzzago, Camilla Gabanelli, Elena Lo Presti, Alessandra Lai, Alessia Rezza, Giovanni Galli, Massimo Bino, Silvia Ciccozzi, Massimo PLoS One Research Article Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis mainly transmitted by ticks that causes severe hemorrhagic fever and has a mortality rate of 5-60%. The first outbreak of CCHF occurred in the Crimean peninsula in 1944-45 and it has recently emerged in the Balkans and eastern Mediterranean. In order to reconstruct the origin and pathway of the worldwide dispersion of the virus at global and regional (eastern European) level, we investigated the phylogeography of the infection by analysing 121 publicly available CCHFV S gene sequences including two recently characterised Albanian isolates. The spatial and temporal phylogeny was reconstructed using a Bayesian Markov chain Monte Carlo approach, which estimated a mean evolutionary rate of 2.96 x 10(-4) (95%HPD=1.6 and 4.7 x 10(-4)) substitutions/site/year for the analysed fragment. All of the isolates segregated into seven highly significant clades that correspond to the known geographical clades: in particular the two new isolates from northern Albania clustered significantly within the Europe 1 clade. Our phylogeographical reconstruction suggests that the global CCHFV clades originated about one thousand years ago from a common ancestor probably located in Africa. The virus then spread to Asia in the XV century and entered Europe on at least two occasions: the first in the early 1800s, when a still circulating but less or non-pathogenic virus emerged in Greece and Turkey, and the second in the early 1900s, when a pathogenic CCHFV strain began to spread in eastern Europe. The most probable location for the origin of this European clade 1 was Russia, but Turkey played a central role in spreading the virus throughout Europe. Given the close proximity of the infected areas, our data suggest that the movement of wild and domestic ungulates from endemic areas was probably the main cause of the dissemination of the virus in eastern Europe. Public Library of Science 2013-11-04 /pmc/articles/PMC3817137/ /pubmed/24223988 http://dx.doi.org/10.1371/journal.pone.0079663 Text en © 2013 Zehender et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zehender, Gianguglielmo Ebranati, Erika Shkjezi, Renata Papa, Anna Luzzago, Camilla Gabanelli, Elena Lo Presti, Alessandra Lai, Alessia Rezza, Giovanni Galli, Massimo Bino, Silvia Ciccozzi, Massimo Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title | Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title_full | Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title_fullStr | Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title_full_unstemmed | Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title_short | Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe |
title_sort | bayesian phylogeography of crimean-congo hemorrhagic fever virus in europe |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817137/ https://www.ncbi.nlm.nih.gov/pubmed/24223988 http://dx.doi.org/10.1371/journal.pone.0079663 |
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