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Prolonged Bioluminescence Monitoring in Mouse Ex Vivo Bone Culture Revealed Persistent Circadian Rhythms in Articular Cartilages and Growth Plates
The bone is a metabolically active organ which undergoes repeated remodeling cycles of bone resorption and formation. In this study, we revealed a robust and extremely long-lasting circadian rhythm in ex vivo culture maintained for over six months from the femoral bone of a PERIOD2(Luciferase) mouse...
Autores principales: | Okubo, Naoki, Minami, Yoichi, Fujiwara, Hiroyoshi, Umemura, Yasuhiro, Tsuchiya, Yoshiki, Shirai, Toshiharu, Oda, Ryo, Inokawa, Hitoshi, Kubo, Toshikazu, Yagita, Kazuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817244/ https://www.ncbi.nlm.nih.gov/pubmed/24223788 http://dx.doi.org/10.1371/journal.pone.0078306 |
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