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p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia
BACKGROUND: Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6 (Tnv-6) induces p53-dependent apoptosis in many malignant cells. In contrast, Tnv-6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulation of autophagy, without increasing p53-pathway a...
Autores principales: | Groves, M J, Johnson, C E, James, J, Prescott, A R, Cunningham, J, Haydock, S, Pepper, C, Fegan, C, Pirrie, L, Westwood, N J, Coates, P J, Ganley, I G, Tauro, S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817336/ https://www.ncbi.nlm.nih.gov/pubmed/24091621 http://dx.doi.org/10.1038/bjc.2013.601 |
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