Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2

BACKGROUND: The objective of this study was to characterise the mechanism underlying acquired resistance to temsirolimus, an inhibitor of mammalian target of rapamycin (mTOR), in renal cell carcinoma (RCC). METHODS: A parental human RCC cell line, ACHN (ACHN/P), was continuously exposed to increasin...

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Detalles Bibliográficos
Autores principales: Harada, K, Miyake, H, Kumano, M, Fujisawa, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817337/
https://www.ncbi.nlm.nih.gov/pubmed/24091619
http://dx.doi.org/10.1038/bjc.2013.602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817337/
https://www.ncbi.nlm.nih.gov/pubmed/24091619
http://dx.doi.org/10.1038/bjc.2013.602

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