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Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumour agents

BACKGROUND: In cycling tumour cells, the binary cyclin-dependent kinase Cdk4/cyclin D or Cdk2/cyclin E complex is inhibited by p21 following DNA damage to induce G1 cell-cycle arrest. However, it is not known whether other proteins are also recruited within Cdk complexes, or their role, and this was...

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Detalles Bibliográficos
Autores principales:	He, G, Kuang, J, Koomen, J, Kobayashi, R, Khokhar, A R, Siddik, Z H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817341/ https://www.ncbi.nlm.nih.gov/pubmed/24104967 http://dx.doi.org/10.1038/bjc.2013.613

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