Cargando…
Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdi...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817344/ https://www.ncbi.nlm.nih.gov/pubmed/24113141 http://dx.doi.org/10.1038/bjc.2013.627 |
_version_ | 1782478060404080640 |
---|---|
author | Ripping, T M Verbeek, A L M van der Waal, D Otten, J D M den Heeten, G J Fracheboud, J de Koning, H J Broeders, M J M |
author_facet | Ripping, T M Verbeek, A L M van der Waal, D Otten, J D M den Heeten, G J Fracheboud, J de Koning, H J Broeders, M J M |
author_sort | Ripping, T M |
collection | PubMed |
description | BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdiagnosis. This study proposes a more appropriate way of analysing trends. METHODS: Breast cancer mortality (1950–2009) and incidence data (1975–2009) were obtained from Statistics Netherlands, ‘Stg. Medische registratie' and the National Cancer Registry in the Netherlands for women aged 25–85 years. Data were visualised in age–birth cohort and age–period figures. RESULTS: Birth cohorts invited to participate in the mammographic screening programme showed a deflection in the breast cancer mortality rates within the first 5 years after invitation. Thereafter, the mortality rate increased, although less rapidly than in uninvited birth cohorts. Furthermore, invited birth cohorts showed a sharp increase in invasive breast cancer incidence rate during the first 5 years of invitation, followed by a moderate increase during the following screening years and a decline after passing the upper age limit. CONCLUSION: When applying a trend study to estimate the impact of mammographic screening, we recommend using a birth cohort approach. |
format | Online Article Text |
id | pubmed-3817344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38173442014-10-29 Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts Ripping, T M Verbeek, A L M van der Waal, D Otten, J D M den Heeten, G J Fracheboud, J de Koning, H J Broeders, M J M Br J Cancer Epidemiology BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdiagnosis. This study proposes a more appropriate way of analysing trends. METHODS: Breast cancer mortality (1950–2009) and incidence data (1975–2009) were obtained from Statistics Netherlands, ‘Stg. Medische registratie' and the National Cancer Registry in the Netherlands for women aged 25–85 years. Data were visualised in age–birth cohort and age–period figures. RESULTS: Birth cohorts invited to participate in the mammographic screening programme showed a deflection in the breast cancer mortality rates within the first 5 years after invitation. Thereafter, the mortality rate increased, although less rapidly than in uninvited birth cohorts. Furthermore, invited birth cohorts showed a sharp increase in invasive breast cancer incidence rate during the first 5 years of invitation, followed by a moderate increase during the following screening years and a decline after passing the upper age limit. CONCLUSION: When applying a trend study to estimate the impact of mammographic screening, we recommend using a birth cohort approach. Nature Publishing Group 2013-10-29 2013-10-10 /pmc/articles/PMC3817344/ /pubmed/24113141 http://dx.doi.org/10.1038/bjc.2013.627 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Ripping, T M Verbeek, A L M van der Waal, D Otten, J D M den Heeten, G J Fracheboud, J de Koning, H J Broeders, M J M Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title | Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title_full | Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title_fullStr | Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title_full_unstemmed | Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title_short | Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
title_sort | immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817344/ https://www.ncbi.nlm.nih.gov/pubmed/24113141 http://dx.doi.org/10.1038/bjc.2013.627 |
work_keys_str_mv | AT rippingtm immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT verbeekalm immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT vanderwaald immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT ottenjdm immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT denheetengj immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT fracheboudj immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT dekoninghj immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts AT broedersmjm immediateanddelayedeffectsofmammographicscreeningonbreastcancermortalityandincidenceinbirthcohorts |