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Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts

BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdi...

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Autores principales: Ripping, T M, Verbeek, A L M, van der Waal, D, Otten, J D M, den Heeten, G J, Fracheboud, J, de Koning, H J, Broeders, M J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817344/
https://www.ncbi.nlm.nih.gov/pubmed/24113141
http://dx.doi.org/10.1038/bjc.2013.627
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author Ripping, T M
Verbeek, A L M
van der Waal, D
Otten, J D M
den Heeten, G J
Fracheboud, J
de Koning, H J
Broeders, M J M
author_facet Ripping, T M
Verbeek, A L M
van der Waal, D
Otten, J D M
den Heeten, G J
Fracheboud, J
de Koning, H J
Broeders, M J M
author_sort Ripping, T M
collection PubMed
description BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdiagnosis. This study proposes a more appropriate way of analysing trends. METHODS: Breast cancer mortality (1950–2009) and incidence data (1975–2009) were obtained from Statistics Netherlands, ‘Stg. Medische registratie' and the National Cancer Registry in the Netherlands for women aged 25–85 years. Data were visualised in age–birth cohort and age–period figures. RESULTS: Birth cohorts invited to participate in the mammographic screening programme showed a deflection in the breast cancer mortality rates within the first 5 years after invitation. Thereafter, the mortality rate increased, although less rapidly than in uninvited birth cohorts. Furthermore, invited birth cohorts showed a sharp increase in invasive breast cancer incidence rate during the first 5 years of invitation, followed by a moderate increase during the following screening years and a decline after passing the upper age limit. CONCLUSION: When applying a trend study to estimate the impact of mammographic screening, we recommend using a birth cohort approach.
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spelling pubmed-38173442014-10-29 Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts Ripping, T M Verbeek, A L M van der Waal, D Otten, J D M den Heeten, G J Fracheboud, J de Koning, H J Broeders, M J M Br J Cancer Epidemiology BACKGROUND: Trend studies investigating the impact of mammographic screening usually display age-specific mortality and incidence rates over time, resulting in an underestimate of the benefit of screening, that is, mortality reduction, and an overestimate of its major harmful effect, that is, overdiagnosis. This study proposes a more appropriate way of analysing trends. METHODS: Breast cancer mortality (1950–2009) and incidence data (1975–2009) were obtained from Statistics Netherlands, ‘Stg. Medische registratie' and the National Cancer Registry in the Netherlands for women aged 25–85 years. Data were visualised in age–birth cohort and age–period figures. RESULTS: Birth cohorts invited to participate in the mammographic screening programme showed a deflection in the breast cancer mortality rates within the first 5 years after invitation. Thereafter, the mortality rate increased, although less rapidly than in uninvited birth cohorts. Furthermore, invited birth cohorts showed a sharp increase in invasive breast cancer incidence rate during the first 5 years of invitation, followed by a moderate increase during the following screening years and a decline after passing the upper age limit. CONCLUSION: When applying a trend study to estimate the impact of mammographic screening, we recommend using a birth cohort approach. Nature Publishing Group 2013-10-29 2013-10-10 /pmc/articles/PMC3817344/ /pubmed/24113141 http://dx.doi.org/10.1038/bjc.2013.627 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Ripping, T M
Verbeek, A L M
van der Waal, D
Otten, J D M
den Heeten, G J
Fracheboud, J
de Koning, H J
Broeders, M J M
Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title_full Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title_fullStr Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title_full_unstemmed Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title_short Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
title_sort immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817344/
https://www.ncbi.nlm.nih.gov/pubmed/24113141
http://dx.doi.org/10.1038/bjc.2013.627
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