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Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that undergoes extensive phase I and II metabolism. To better understand the kinetics of this process and to characterize the dynamic changes in metabolism and pharmacokinetics (PK) between children and adults, we developed a physi...

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Detalles Bibliográficos
Autores principales:	Jiang, X-L, Zhao, P, Barrett, J S, Lesko, L J, Schmidt, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817375/ https://www.ncbi.nlm.nih.gov/pubmed/24132164 http://dx.doi.org/10.1038/psp.2013.55

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